For some function of "efficient", yes.  You'd need to walk `getSignaturesForAddress` for the mint address. [This](https://solana.stackexchange.com/a/277/36) answer is a good place to start.

EDIT: Given that the `Transfer` instruction doesn't reference the mint address, this solution would be incomplete.  You'd probably have to do some awful graph walk to each account from each `MintTo` instruction on the mint