For some function of "efficient", yes. You'd need to walk getSignaturesForAddress for the mint address. This answer is a good place to start

For some function of "efficient", yes. You'd need to walk getSignaturesForAddress for the mint address. This answer is a good place to start.

EDIT: Given that the Transfer instruction doesn't reference the mint address, this solution would be incomplete. You'd probably have to do some awful graph walk to each account from each MintTo instruction on the mint